T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.
نویسندگان
چکیده
منابع مشابه
T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production
The antigen-specific receptors of T and B lymphocytes are generated by somatic recombination between noncontiguous gene segments encoding the variable portions of these molecules. The semirandom nature of this process, while desirable for the generation of diversity, has been thought to exact a high price in terms of sterile (out-of-frame) products. Historically, the majority of T lymphocytes g...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1995
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.182.1.121